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science P-selectin glycoprotein leukocytes adhere endothelial cells interaction extracellular domain matrix surface type outer inner leaflet lipid bilayer sphingolipid raft recruit membrane protein cholesterol kinks saturated hydrocarbon chain fluidity inflammation chemokine proteoglycan transmembrane receptor cascade signalling reaction covalent fatty acid chain signal spectrin tetramer hexagonal network skeleton cytoskeleton filaments distribution cytosol microvilli actin bundles cross-link gel binding monomers plus end polymerization dynamic directional disassembly severing fragment depolymerize microtubules dimers tubulin stabilize cargo vesicle motor mitochondria centrosome pores nuclear envelope mRNA ribosome translate cytoplasm synthesis secrete translocator endoplasmic reticulum lumen integral glycosylation Golgi embedded diffuse G-protein coupled receptor conformation activation subunit change I-Cam immobilize blood adhesion transendothelial migration extravasation nucleus (more)
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