Login | Signup now       

Guest

 Click to see how  

HOME | VIDEOS | DOCUMENTS | COLLECTIONS | UPLOAD | BROADCAST | MY ACCOUNT | FEEDBACK | ABOUT

Share  Title: Inhibitors of leucine-rich repeat kinase-2 protect against m...

 
iConnect (Beta)   |  Like   |    Sponsor  |   Comment   |    Report  

Authors

If you are an author or an inventor or an individual related to the work displayed in this video, you can click on the 'add me as' button to link your researchusa profile to this entry. Doing so automatically puts you on the iConnect network bringing great visibility to all your related work.

    
 
Article

View Cross Ref (Beta)

Your Edit is Valuable. Editor's names show on Edit pannel.Edit this article  

 
Crawl to journal paper DOI - 10.1038/nm.2199

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. In this paper, Byoung Dae Lee1, Joo-Ho Shin1, Jackalina VanKampen, Leonard Petrucelli, Andrew B West1, Han Seok Ko1, Yun-Il Lee1, Kathleen A Maguire-Zeiss, William J Bowers, Howard J Federoff, Valina L Dawson1 & Ted M Dawson have identified inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. The results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease. 
[var.addon_information]

 
Related Documents
Motor neuron disease
Quasi-one-dimensional models for glassy dynamics
Primitivism in Paul Gauguin's Where Do We Come From? What Are We? Where Are We Going? (1898)
Modeling and Simulation of Mixing Layer Flows For Rocket Engine Film Cooling
Complex Classification Using Advanced Machine Learning Techniques
NOTAR Helicopter
Experimental Study of Compressible Pipe Flow with Friction and Heat Addition
The Role of Density Gradient in Liquid Rocket Engine Combustion Instability
Hints for understanding low speed wind tunnels
 
Member Documents
Experimental Study of Compressible Pipe Flow with Friction and Heat Addition
MATLAB Tutorial for processing Signals and Systems
 

Keywords
Parkinson  kinase  LRRK2  
 
 About This Video
 
 Subject Medical Sciences
 Category Journal Paper Discussion
 Duration moderate
 Views 2292
 Added 12-09-10
 Contributor    autocrawler
 Add to Favourites
 Report Abuse
 
 Related Videos
 See More

Stem

 RunTime  00:09:00
 Uploaded  08-01-08
 Views  2311
   
 Stem Cell Research Docume...

Small

 RunTime  00:03:13
 Uploaded  27-12-07
 Views  2129
   
 Small Device Enhances Dru...

Immunodeficiency

 RunTime  00:50:33
 Uploaded  05-11-07
 Views  2107
   
 Immunodeficiency Diseases

Surviving

 RunTime  00:05:35
 Uploaded  25-11-07
 Views  2178
   
 Surviving an Earthquake

How

 RunTime  00:00:02
 Uploaded  23-10-07
 Views  2199
   
 How RSS Feeds Work

IBM

 RunTime  moderate
 Uploaded  16-09-10
 Views  2634
   
 IBM Research Computationa...

New

 RunTime  00:10:39
 Uploaded  08-01-08
 Views  2203
   
 New Diabetes Research

Leaping

 RunTime  moderate
 Uploaded  10-09-10
 Views  2570
   
 Leaping shampoo and the s...

Saturn:

 RunTime  00:09:54
 Uploaded  12-01-10
 Views  2459
   
 Saturn: A Giant Thrust in...

High

 RunTime  00:00:09
 Uploaded  13-02-09
 Views  2663
   
 High voltage disconnect s...

3D

 RunTime  moderate
 Uploaded  26-10-12
 Views  448
   
 3D Printing from MIT

Experiments

 RunTime  00:00:02
 Uploaded  21-11-07
 Views  2136
   
 Experiments with the Mobi...

Banked

 RunTime  moderate
 Uploaded  20-09-10
 Views  2311
   
 Banked blood doesn't deli...

Lecture:

 RunTime  01:22:14
 Uploaded  27-12-07
 Views  2343
   
 Lecture: Probabilistic Me...

Manifold

 RunTime  00:31:19
 Uploaded  14-07-08
 Views  2587
   
 Manifold Microchannel Coo...

UHN

 RunTime  00:09:40
 Uploaded  20-12-07
 Views  2271
   
 UHN Finding the Answers: ...

The

 RunTime  00:06:50
 Uploaded  27-12-07
 Views  2230
   
 The Phoenix Mars Lander

Lisa

 RunTime  00:06:50
 Uploaded  10-01-08
 Views  2950
   
 Lisa Randall Lecture

 Member Videos
 See More

Post-copulatory

 RunTime  moderate
 Uploaded  12-09-10
 Views  4135
   
 Post-copulatory sexual se...

Nobel

 RunTime  moderate
 Uploaded  10-09-10
 Views  3068
   
 Nobel Laureate Venki Rama...

Echo

 RunTime  00:06:36
 Uploaded  04-05-09
 Views  3016
   
 Echo Cardio Gram and Colo...

Lisa

 RunTime  00:06:50
 Uploaded  10-01-08
 Views  2950
   
 Lisa Randall Lecture

Orbital

 RunTime  00:36:02
 Uploaded  26-06-10
 Views  2856
   
 Orbital Mechanics

Whales

 RunTime  moderate
 Uploaded  10-09-10
 Views  2684
   
 Whales originated from aq...

IBM

 RunTime  moderate
 Uploaded  16-09-10
 Views  2634
   
 IBM Research Computationa...

NASA

 RunTime  moderate
 Uploaded  15-09-10
 Views  2625
   
 NASA and Caltech Test Ste...

MIT

 RunTime  moderate
 Uploaded  07-10-10
 Views  2621
   
 MIT Researcher Joe Pompei...

How

 RunTime  00:18:29
 Uploaded  25-06-10
 Views  2590
   
 How Airplanes Fly

Leaping

 RunTime  moderate
 Uploaded  10-09-10
 Views  2570
   
 Leaping shampoo and the s...

How

 RunTime  00:08:14
 Uploaded  22-12-09
 Views  2559
   
 How to Solve Differential...

 

 

Comments | Queries | Clarifications