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Share  Title: Inhibitors of leucine-rich repeat kinase-2 protect against m...

 
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Crawl to journal paper DOI - 10.1038/nm.2199

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. In this paper, Byoung Dae Lee1, Joo-Ho Shin1, Jackalina VanKampen, Leonard Petrucelli, Andrew B West1, Han Seok Ko1, Yun-Il Lee1, Kathleen A Maguire-Zeiss, William J Bowers, Howard J Federoff, Valina L Dawson1 & Ted M Dawson have identified inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. The results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease. 
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Keywords
Parkinson  kinase  LRRK2  
 
 About This Video
 
 Subject Medical Sciences
 Category Journal Paper Discussion
 Duration moderate
 Views 2323
 Added 12-09-10
 Contributor    autocrawler
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