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The term motor neuron classically applies to neurons located in the CNS that project their axons outside the CNS and directly or indirectly control muscles.The term "amyotrophic lateral sclerosis" is derived from the combination of the clinical examination finding of amyotrophy with the pathological finding of lateral sclerosis. Amyotrophic lateral sclerosis (ALS), first described by Charcot in the nineteenth century.ALS is a relentlessly progressive, presently incurable, neurodegenerative disorder that causes muscle weakness, disability, and eventually death.ALS is also known as "Lou Gehrig's Disease," after the famous New York Yankee baseball player who was affected with the disease
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